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THCV
Tetrahydrocannabivarin
Pronounced: tee-aych-see-VAR
THCV (Tetrahydrocannabivarin) is a psychoactive minor cannabinoid. Learn about THCV, the unique cannabinoid that may suppress appetite. Discover its energizing effects, metabolic research, and how it differs from THC..
Boiling Point
428°F (220°C)
Formula
C₁₉H₂₆O₂
Legal Status
Schedule I federally; legal gray area in some states
May cause impairment. Do not drive or operate machinery after use.
What is THCV?
THCV (tetrahydrocannabivarin) is a propyl analog of THC with unique pharmacological properties. Unlike THC, THCV acts as a CB1 receptor antagonist at low doses, potentially blocking some of THC's effects. At higher doses, it becomes a CB1 agonist and produces psychoactive effects, though shorter-lasting than THC. THCV is being studied for metabolic syndrome, appetite suppression, and diabetes.
How THCV Works
THCV displays dose-dependent behavior at CB1 receptors: at low doses it acts as an antagonist (blocking receptor activity), while at higher doses it becomes an agonist (activating receptors). This unique profile means low-dose THCV may block some THC effects, while high-dose THCV produces its own psychoactive effects. THCV also interacts with CB2 receptors and has a shorter duration than THC.
Researched Effects
Appetite Suppression
Moderate EvidenceUnlike THC which stimulates appetite, THCV may suppress appetite through CB1 antagonism.
✓ Compliant Language
Research suggests appetite-modulating properties
✗ Avoid Saying
Causes weight loss or treats obesity
Energizing
Emerging ResearchUsers report more energizing, clear-headed effects compared to THC, with shorter duration.
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Often reported as more energizing than THC
✗ Avoid Saying
Gives energy or treats fatigue
Sources
Glycemic Control
Emerging ResearchPreclinical research suggests potential effects on blood sugar regulation.
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Being researched for metabolic applications
✗ Avoid Saying
Treats diabetes or controls blood sugar
Sources
Medical Applications
Metabolic Syndrome
Emerging ResearchBeing studied for effects on appetite, weight, and metabolic markers.
Type 2 Diabetes
Emerging ResearchEarly research exploring glycemic control potential.
Dosing Guidance
THCV dosing is complex due to its dose-dependent effects. Low doses (under 10mg) may act as a CB1 antagonist, while higher doses produce THC-like effects. Effects are shorter-lasting than THC. Found naturally in higher concentrations in certain African landrace strains.
Safety Information
THCV is psychoactive at higher doses. Effects are shorter-lasting than THC (1-2 hours vs 3-4 hours). May block some THC effects at low doses. Not recommended for those seeking appetite stimulation.
Potential Side Effects
- Psychoactive effects at higher doses
- Shorter duration than THC
- May suppress appetite
- Dry mouth
- Possible anxiety at high doses
Drug Interactions
Limited data. May interact with medications metabolized by CYP450 enzymes. Consult physician if taking other medications.
Scientific References
Riedel G, et al. • British Journal of Pharmacology (2009)
PubMed ID: 19378378
Demonstrated CB1 antagonist/agonist dose-dependent effects.
Cawthorne MA, et al. • International Cannabinoid Research Society (2007)
Early research on THCV appetite suppression mechanisms.
Jadoon KA, et al. • Diabetes Care (2016)
PubMed ID: 27573936
Clinical trial showing THCV significantly decreased fasting plasma glucose.
Frequently Asked Questions
What is THCV?
THCV (tetrahydrocannabivarin) is a cannabinoid related to THC but with unique properties. It acts as a CB1 antagonist at low doses and may suppress appetite, unlike THC which stimulates hunger.
Does THCV get you high?
At higher doses, yes. THCV is psychoactive but produces effects described as more energizing and clear-headed than THC, with a shorter duration (1-2 hours vs 3-4 hours for THC).
Why is THCV called "diet weed"?
Because unlike THC which causes "the munchies," THCV may suppress appetite through its CB1 antagonist properties. It's being researched for potential weight management applications.
Which strains are high in THCV?
African landrace strains like Durban Poison, as well as hybrids like Doug's Varin, Pineapple Purps, and Jack the Ripper tend to have higher THCV content.
Quick Facts
- Full Name
- Tetrahydrocannabivarin
- Category
- minor Cannabinoid
- Psychoactive
- Yes
- Boiling Point
- 428°F (220°C)
- Formula
- C₁₉H₂₆O₂
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Medical Disclaimer
This content is for educational purposes only and is not medical advice. Consult a healthcare provider before using cannabis products.
Individual Variation
Cannabis affects everyone differently based on genetics, tolerance, and other factors. What works for one person may not work for another.
Start Low, Go Slow
Always begin with the lowest effective dose and increase gradually to minimize risk of adverse effects.