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Missouri Medical Marijuana Qualifying Conditions

Missouri's medical marijuana program operates under Mo. Const. art. XIV ss 1(6) with one of the broadest catch-alls in the nation. The constitution names cancer, epilepsy, glaucoma, intractable migraines, PTSD, HIV/AIDS, and terminal illness, plus any chronic condition causing severe persistent pain or muscle spasms, plus a safer-alternative pathway for conditions normally treated with dependence-forming medications, plus a physician-discretion catch-all for any other chronic or debilitating condition.

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By Dr. Kevin Kargman, DOLicensed MO Physician #2022027983

Audited: January 1, 2026

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Missouri Qualifying Conditions: Detailed Guide

What conditions qualify for medical marijuana in Missouri?

Missouri allows medical marijuana for any chronic, debilitating condition a physician believes would benefit from cannabis treatment. This includes chronic pain, PTSD, cancer, epilepsy, anxiety, migraines, and more. MMJ.com offers telehealth evaluations for $149.99 with same-day certification and a 100% money-back guarantee.## What is the complete list of Missouri qualifying conditions?

Missouri's Medical Marijuana Program, administered by the Department of Health and Senior Services (DHSS), has one of the most patient-friendly qualifying criteria in the country. Physicians can recommend cannabis for:

Specifically Listed Conditions

Physician Discretion Clause

Any chronic, debilitating, or other medical condition that a physician determines medical marijuana could benefit,including:

  • Anxiety
  • Depression
  • Insomnia
  • Fibromyalgia
  • Neuropathy
  • Arthritis
  • And many more

This makes Missouri's program one of the most accessible in the nation.

About the Qualifying Medical Conditions

Below is information about each qualifying condition and the research that informed Missouri's decision to include it in the state program.

Chronic Pain, Migraines, and Muscle Spasms

Chronic pain, intractable migraines, and muscle spasms are approved qualifying conditions under Missouri's medical marijuana program. Missouri included these conditions based on systematic reviews examining cannabinoid use among patients with chronic pain conditions.

PTSD

PTSD is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research examining cannabinoid use among patients with PTSD.

Epilepsy and Seizure Disorders

Seizure disorders, including epilepsy, are approved qualifying conditions under Missouri's medical marijuana program. Missouri included these conditions based on clinical trial research examining CBD in patients with treatment-resistant epilepsy.

Cancer, HIV/AIDS, and Terminal Illness

These are approved qualifying conditions under Missouri's medical marijuana program. Missouri included these conditions based on research examining cannabinoid use among patients experiencing treatment-related symptoms or end-of-life care needs.

Multiple Sclerosis

MS is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on clinical research examining cannabinoid use in patients with MS-related spasticity.

Parkinson's Disease

Parkinson's Disease is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research examining cannabinoid use among Parkinson's patients.

Huntington's Disease

Huntington's Disease is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research examining cannabinoid use in patients with neurodegenerative conditions.

Crohn's Disease and Ulcerative Colitis

Inflammatory bowel diseases are approved qualifying conditions under Missouri's medical marijuana program. Missouri included these conditions based on clinical research examining cannabis use in IBD patients.

Autism Spectrum Disorder

Autism Spectrum Disorder is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research examining cannabis use among patients with autism spectrum disorder.

Glaucoma

Glaucoma is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on early research examining the relationship between cannabinoids and intraocular pressure.

Hepatitis C

Hepatitis C is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research examining cannabis use among patients undergoing antiviral treatment.

ALS

ALS is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research surveying ALS patients about symptom management.

Alzheimer's Disease

Alzheimer's Disease (with agitation) is an approved qualifying condition under Missouri's medical marijuana program. Missouri included this condition based on research examining cannabinoid use in dementia patients.

Physician Discretion Conditions

Missouri's physician discretion clause allows doctors to recommend medical marijuana for any condition they believe would benefit. This is based on Missouri statute and does not require specific research citations for each condition.

Can I petition for a new qualifying condition in Missouri?

Yes, Missouri residents can petition DHSS to add new conditions to the officially listed qualifying conditions. However, due to the physician discretion clause, most debilitating conditions can already be approved by a recommending physician.

Petitions require:

  • Detailed medical evidence
  • Scientific studies supporting cannabis treatment
  • Healthcare professional endorsements

Medical Disclaimer

This page provides information about Missouri's qualifying conditions for medical cannabis. The inclusion of a condition in Missouri's program does not constitute medical advice or a guarantee of therapeutic benefit. Individual results vary. Potential side effects may include dizziness, sedation, and cognitive changes. Always consult a healthcare provider before starting treatment.

Reviewed by MMJ.com Medical Advisory Team Last Updated: December 17, 2025

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FAQ

Common Questions About Missouri Qualifying Conditions

What conditions qualify for a Missouri medical marijuana card?

Missouri's program under Mo. Const. art. XIV ss 1(6) lists cancer, epilepsy, glaucoma, intractable migraines unresponsive to other treatment, debilitating psychiatric disorders (including PTSD when diagnosed by a state-licensed psychiatrist), HIV/AIDS, terminal illness, any chronic medical condition that causes severe persistent pain or persistent muscle spasms (including those associated with MS, seizures, Parkinson's, and Tourette's), any chronic condition normally treated with prescription medications that could lead to dependence (the constitutional safer-alternative pathway), and any other chronic, debilitating, or other medical condition in the professional judgment of a physician.

Can my Missouri doctor recommend medical marijuana for any condition?

Substantially yes. Mo. Const. art. XIV ss 1(6)(j) includes a constitutional catch-all: 'In the professional judgment of a physician, any other chronic, debilitating or other medical condition, including, but not limited to, hepatitis C, ALS, IBD, Crohn's disease, Huntington's disease, autism, neuropathies, sickle cell anemia, agitation of Alzheimer's disease, cachexia, and wasting syndrome.' This makes Missouri one of the broadest open-framework programs in the country.

Does opioid use disorder qualify in Missouri?

Yes. Missouri's constitutional safer-alternative pathway under Mo. Const. art. XIV ss 1(6)(h) covers 'a chronic medical condition that is normally treated with prescription medications that could lead to physical or psychological dependence, when a physician determines that medical use of marijuana could be effective in treating that condition and would serve as a safer alternative to the prescription medication.' This explicitly authorizes certification for opioid use disorder, benzodiazepine dependence, and similar chronic conditions where dependence-forming medications would otherwise be prescribed.

Does chronic pain qualify in Missouri?

Yes. Mo. Const. art. XIV ss 1(6)(f) covers 'A chronic medical condition that causes severe, persistent pain or persistent muscle spasms, including but not limited to those associated with multiple sclerosis, seizures, Parkinson's disease, and Tourette's syndrome.' The constitutional standard is broad; documentation of the chronic nature and severity of the pain is essential.

Does PTSD qualify in Missouri?

Yes, with a documentation requirement. Mo. Const. art. XIV ss 1(6)(g) lists 'debilitating psychiatric disorders, including, but not limited to, post-traumatic stress disorder' as a qualifying condition, BUT specifies that the PTSD diagnosis must be made by a state-licensed psychiatrist. A primary care diagnosis is not sufficient; the certifying physician must verify a psychiatrist-confirmed diagnosis. Common documentation sources include VA mental-health records from the John Cochran VA in St. Louis, the Harry S. Truman VA in Columbia, or the Kansas City VA.

Does anxiety qualify in Missouri?

Anxiety is not specifically named in Mo. Const. art. XIV ss 1(6) but may qualify under the broad catch-all in ss 1(6)(j) ('any other chronic, debilitating or other medical condition') at the certifying physician's professional judgment. Anxiety patients with documented chronic, debilitating symptoms and prior treatment failure routinely qualify in Missouri.

What documentation do I need for Missouri certification?

Missouri certifying physicians need medical records that document your diagnosis. Acceptable records include notes from a primary care physician or specialist, hospital records, imaging or lab reports, pharmacy records, and VA records. For PTSD specifically, a psychiatrist's diagnosis is required. MMJ.com's Missouri-licensed physicians review uploaded records before issuing the certification submitted to the Missouri DHSS patient ID portal.

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Medically reviewed by: Dr. Kevin Kargman, DO·Missouri License #2022027983·NPI 1407810302

Editorial oversight by: John Progar, CEO & FounderLast Verified: May 2026

Last Updated: December 17, 2025